Assay Detail
Functional
CHEMBL889117
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Inhibition of estrogen stimulation in human Ishikawa cells by alkaline phosphatase quantitation
34
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.15 | 8.68 |
| Efficacy | 17 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390020 | — | — | 2 | 8.68 |
| CHEMBL243571 | — | — | 2 | 8.55 |
| CHEMBL244205 | — | — | 2 | 8.49 |
| CHEMBL244206 | — | — | 2 | 8.41 |
| CHEMBL244000 | — | — | 2 | 8.33 |
| CHEMBL390021 | — | — | 2 | 8.32 |
| CHEMBL243791 | — | — | 2 | 8.31 |
| CHEMBL243790 | — | — | 2 | 8.21 |
| CHEMBL244001 | — | — | 2 | 8.17 |
| CHEMBL244207 | — | — | 2 | 8.14 |
| CHEMBL390448 | — | — | 2 | 8.10 |
| CHEMBL243789 | — | — | 2 | 7.97 |
| CHEMBL395291 | — | — | 2 | 7.84 |
| CHEMBL428926 | — | — | 2 | 7.80 |
| CHEMBL243970 | — | — | 2 | 7.79 |
| CHEMBL243999 | — | — | 2 | 7.73 |
| CHEMBL389907 | — | — | 2 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390020 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL243571 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL244205 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL244206 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL244000 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL390021 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL243791 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL243790 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL244001 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL244207 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL390448 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL243789 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL395291 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL428926 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL243970 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL243999 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL389907 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL243571 | — | Efficacy | = | 99.0 | % | - |
| CHEMBL390448 | — | Efficacy | = | 99.0 | % | - |
| CHEMBL428926 | — | Efficacy | = | 93.0 | % | - |
| CHEMBL244207 | — | Efficacy | = | 98.0 | % | - |
| CHEMBL244206 | — | Efficacy | = | 96.0 | % | - |
| CHEMBL390021 | — | Efficacy | = | 97.0 | % | - |
| CHEMBL244205 | — | Efficacy | = | 93.0 | % | - |
| CHEMBL244001 | — | Efficacy | = | 95.0 | % | - |
| CHEMBL390020 | — | Efficacy | = | 100.0 | % | - |
| CHEMBL243999 | — | Efficacy | = | 94.0 | % | - |
| CHEMBL243791 | — | Efficacy | = | 96.0 | % | - |
| CHEMBL243970 | — | Efficacy | = | 95.0 | % | - |
| CHEMBL243790 | — | Efficacy | = | 95.0 | % | - |
| CHEMBL389907 | — | Efficacy | = | 97.0 | % | - |
| CHEMBL395291 | — | Efficacy | = | 95.0 | % | - |
| CHEMBL244000 | — | Efficacy | = | 96.0 | % | - |
| CHEMBL243789 | — | Efficacy | = | 88.0 | % | - |