Assay Detail
Binding
CHEMBL889128
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Inhibition of renin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.00 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390196 | — | — | 1 | 10.17 |
| CHEMBL411885 | — | — | 1 | 9.30 |
| CHEMBL230262 | — | — | 1 | 7.04 |
| CHEMBL230261 | — | — | 1 | 6.92 |
| CHEMBL230367 | — | — | 1 | 6.75 |
| CHEMBL390642 | — | — | 1 | 6.70 |
| CHEMBL230260 | — | — | 1 | 6.19 |
| CHEMBL230153 | — | — | 1 | 5.40 |
| CHEMBL390197 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390196 | — | IC50 | = | 0.067 | nM | 10.17 |
| CHEMBL411885 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL230262 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL230261 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL230367 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL390642 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL230260 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL230153 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL390197 | — | IC50 | = | 27000.0 | nM | 4.57 |