Assay Detail
Functional
CHEMBL889154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of acid-induced calcium influx
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.85 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226723 | — | — | 1 | 9.52 |
| CHEMBL226724 | — | — | 1 | 8.38 |
| CHEMBL226672 | — | — | 1 | 8.16 |
| CHEMBL226671 | — | — | 1 | 6.60 |
| CHEMBL227364 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226723 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL226724 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL226672 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL226671 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL227364 | — | IC50 | = | 270.0 | nM | 6.57 |