Assay Detail
Binding
CHEMBL889249
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Inhibition of PKA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.89 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226625 | — | — | 1 | 8.30 |
| CHEMBL427422 | — | — | 1 | 8.15 |
| CHEMBL438483 | — | — | 1 | 8.05 |
| CHEMBL226898 | — | — | 1 | 7.89 |
| CHEMBL388312 | — | — | 1 | 7.82 |
| CHEMBL226850 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226625 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL427422 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL438483 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL226898 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL388312 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL226850 | — | IC50 | = | 78.0 | nM | 7.11 |