Assay Detail
Functional
CHEMBL889542
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Agonist activity at human GPR40 expressed in HEK-EM 293 cells assessed as increase in intracellular calcium
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 1 | - | - |
| EC50 | 1 | 6.65 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207881 | GW9508 | — | 2 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207881 | GW9508 | EC50 | = | 223.87 | nM | 6.65 |
| CHEMBL207881 | GW9508 | Activity | = | 223.0 | nM | - |