Assay Detail
Binding
CHEMBL889560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ALK5 phosphorylation expressed in Sf9 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229599 | — | — | 1 | 8.00 |
| CHEMBL387748 | — | — | 1 | 7.92 |
| CHEMBL376119 | — | — | 1 | 7.82 |
| CHEMBL389078 | — | — | 1 | 7.68 |
| CHEMBL226734 | — | — | 1 | 7.62 |
| CHEMBL229546 | — | — | 1 | 7.38 |
| CHEMBL387747 | — | — | 1 | 7.34 |
| CHEMBL229598 | — | — | 1 | 7.34 |
| CHEMBL229548 | — | — | 1 | 7.33 |
| CHEMBL229496 | — | — | 1 | 7.14 |
| CHEMBL229654 | — | — | 1 | 7.12 |
| CHEMBL226733 | — | — | 1 | 7.04 |
| CHEMBL229547 | — | — | 1 | 6.92 |
| CHEMBL445934 | — | — | 1 | 6.82 |
| CHEMBL229495 | — | — | 1 | 6.76 |
| CHEMBL229597 | — | — | 1 | 6.58 |
| CHEMBL229497 | — | — | 1 | 6.44 |
| CHEMBL389079 | — | — | 1 | 6.42 |
| CHEMBL440084 | SB-431542 | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229599 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL387748 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL376119 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL389078 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL226734 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL229546 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL387747 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL229598 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL229548 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL229496 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL229654 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL226733 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL229547 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL445934 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL229495 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL229597 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL229497 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL389079 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL440084 | SB-431542 | IC50 | = | 1542.0 | nM | 5.81 |