Assay Detail
Binding
CHEMBL889603
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Inhibition of Escherichia coli DHFR
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438664 | — | — | 1 | 8.70 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.18 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 7.70 |
| CHEMBL389887 | — | — | 1 | 7.05 |
| CHEMBL388120 | — | — | 1 | 6.85 |
| CHEMBL226954 | — | — | 1 | 6.85 |
| CHEMBL226953 | — | — | 1 | 6.82 |
| CHEMBL226952 | — | — | 1 | 6.82 |
| CHEMBL387901 | — | — | 1 | 6.80 |
| CHEMBL227063 | — | — | 1 | 6.80 |
| CHEMBL389686 | — | — | 1 | 6.77 |
| CHEMBL227007 | — | — | 1 | 6.55 |
| CHEMBL227010 | — | — | 1 | 6.50 |
| CHEMBL388121 | — | — | 1 | 6.50 |
| CHEMBL227009 | — | — | 1 | 6.06 |
| CHEMBL227064 | — | — | 1 | 5.50 |
| CHEMBL227008 | — | — | 1 | - |
| CHEMBL226955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438664 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL389887 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL388120 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL226954 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL226953 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL226952 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL387901 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL227063 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL389686 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL227007 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL227010 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL388121 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL227009 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL227064 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL227008 | — | IC50 | - | — | - | |
| CHEMBL226955 | — | IC50 | - | — | - |