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Assay Detail

CHEMBL889768

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Functional
Antiviral activity against HCV in Huh 5-2 cells
ChEMBL ↗
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity.
Puerstinger G, Paeshuyse J, Heinrich S, Mohr J, Schraffl N, De Clercq E, Neyts J.
Bioorg Med Chem Lett (2007) 17 : 5111 -5114
PubMed 17656093 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 56 5.48 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL243972 — — 1 7.10
CHEMBL242485 — — 1 7.00
CHEMBL244810 — — 1 6.70
CHEMBL390260 — — 1 6.70
CHEMBL396486 — — 1 6.70
CHEMBL398216 — — 1 6.70
CHEMBL243973 — — 1 6.52
CHEMBL390397 — — 1 6.52
CHEMBL428043 — — 1 6.52
CHEMBL390396 — — 1 6.52
CHEMBL245050 — — 1 6.52
CHEMBL388232 — — 1 6.44
CHEMBL242913 — — 1 6.37
CHEMBL242269 — — 1 6.30
CHEMBL397219 — — 1 6.22
CHEMBL243315 — — 1 6.22
CHEMBL242911 — — 1 6.16
CHEMBL243546 — — 1 6.00
CHEMBL243535 — — 1 5.92
CHEMBL242270 — — 1 5.89
CHEMBL242700 — — 1 5.89
CHEMBL388021 — — 1 5.80
CHEMBL398229 — — 1 5.52
CHEMBL242912 — — 1 5.31
CHEMBL395315 — — 1 5.28
CHEMBL397265 — — 1 5.11
CHEMBL390395 — — 1 4.96
CHEMBL242698 — — 1 4.80
CHEMBL242699 — — 1 4.57
CHEMBL428740 — — 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL243972 — EC50 = 80.0 nM 7.10
CHEMBL242485 — EC50 = 100.0 nM 7.00
CHEMBL390260 — EC50 = 200.0 nM 6.70
CHEMBL396486 — EC50 = 200.0 nM 6.70
CHEMBL398216 — EC50 = 200.0 nM 6.70
CHEMBL244810 — EC50 = 200.0 nM 6.70
CHEMBL243973 — EC50 = 300.0 nM 6.52
CHEMBL390397 — EC50 = 300.0 nM 6.52
CHEMBL428043 — EC50 = 300.0 nM 6.52
CHEMBL390396 — EC50 = 300.0 nM 6.52
CHEMBL245050 — EC50 = 300.0 nM 6.52
CHEMBL388232 — EC50 = 360.0 nM 6.44
CHEMBL242913 — EC50 = 430.0 nM 6.37
CHEMBL242269 — EC50 = 500.0 nM 6.30
CHEMBL243315 — EC50 = 600.0 nM 6.22
CHEMBL397219 — EC50 = 600.0 nM 6.22
CHEMBL242911 — EC50 = 700.0 nM 6.16
CHEMBL243546 — EC50 = 1000.0 nM 6.00
CHEMBL243535 — EC50 = 1200.0 nM 5.92
CHEMBL242270 — EC50 = 1300.0 nM 5.89
CHEMBL242700 — EC50 = 1300.0 nM 5.89
CHEMBL388021 — EC50 = 1600.0 nM 5.80
CHEMBL398229 — EC50 = 3000.0 nM 5.52
CHEMBL242912 — EC50 = 4940.0 nM 5.31
CHEMBL395315 — EC50 = 5200.0 nM 5.28
CHEMBL397265 — EC50 = 7700.0 nM 5.11
CHEMBL390395 — EC50 = 11000.0 nM 4.96
CHEMBL242698 — EC50 = 16000.0 nM 4.80
CHEMBL242699 — EC50 = 27000.0 nM 4.57
CHEMBL428740 — EC50 = 36000.0 nM 4.44
CHEMBL242484 — EC50 = 39000.0 nM 4.41
CHEMBL242483 — EC50 = 43000.0 nM 4.37
CHEMBL388705 — EC50 = 45000.0 nM 4.35
CHEMBL242017 — EC50 = 47000.0 nM 4.33
CHEMBL396485 — EC50 = 48000.0 nM 4.32
CHEMBL245275 — EC50 = 53000.0 nM 4.28
CHEMBL243534 — EC50 = 69000.0 nM 4.16
CHEMBL243316 — EC50 = 75000.0 nM 4.12
CHEMBL388706 — EC50 = 75000.0 nM 4.12
CHEMBL395550 — EC50 = 76000.0 nM 4.12
CHEMBL243785 — EC50 = 84000.0 nM 4.08
CHEMBL428396 — EC50 = 84000.0 nM 4.08
CHEMBL242239 — EC50 = 95000.0 nM 4.02
CHEMBL440224 — EC50 > 152000.0 nM -
CHEMBL394597 — EC50 > 144000.0 nM -
CHEMBL245026 — EC50 > 150000.0 nM -
CHEMBL395507 — EC50 > 91000.0 nM -
CHEMBL243764 — EC50 > 85000.0 nM -
CHEMBL242238 — EC50 > 162000.0 nM -
CHEMBL395802 — EC50 > 52000.0 nM -