Assay Detail
Functional
CHEMBL889822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.18 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | 10.72 |
| CHEMBL234520 | — | — | 1 | 8.82 |
| CHEMBL438313 | — | — | 1 | 8.72 |
| CHEMBL391598 | — | — | 1 | 8.34 |
| CHEMBL391808 | — | — | 1 | 8.33 |
| CHEMBL233915 | — | — | 1 | 8.10 |
| CHEMBL232947 | — | — | 1 | 8.07 |
| CHEMBL391393 | — | — | 1 | 8.03 |
| CHEMBL438140 | — | — | 1 | 7.82 |
| CHEMBL391807 | — | — | 1 | 7.59 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 7.40 |
| CHEMBL234752 | — | — | 1 | 7.29 |
| CHEMBL392462 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | EC50 | = | 0.019 | nM | 10.72 |
| CHEMBL234520 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL438313 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL391598 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL391808 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL233915 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL232947 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL391393 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL438140 | — | EC50 | = | 15.2 | nM | 7.82 |
| CHEMBL391807 | — | EC50 | = | 25.5 | nM | 7.59 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL234752 | — | EC50 | = | 51.5 | nM | 7.29 |
| CHEMBL392462 | — | EC50 | = | 69.5 | nM | 7.16 |