Assay Detail

CHEMBL890101

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Binding

Inhibition of HCV 1b NS3 protease

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus subtype 1b
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.

Ortqvist P, Peterson SD, Kerblom E, Gossas T, Sabnis YA, Fransson R, Lindeberg G, Helena Danielson U, Karlén A, Sandström A.
Bioorg Med Chem (2007) 15 : 1448 -1474
PubMed 17113777 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.18	9.18

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL297884	CILUPREVIR	2.0	1	9.18

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL297884	CILUPREVIR	Ki	=	0.66	nM	9.18