Assay Detail
Binding
CHEMBL890163
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Inhibition of HIV1 recombinant reverse transcriptase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226735 | — | — | 1 | 7.70 |
| CHEMBL389466 | — | — | 1 | 6.26 |
| CHEMBL389237 | — | — | 1 | 6.22 |
| CHEMBL226787 | — | — | 1 | 6.17 |
| CHEMBL226786 | — | — | 1 | 6.07 |
| CHEMBL428685 | — | — | 1 | 6.00 |
| CHEMBL267920 | — | — | 1 | - |
| CHEMBL226788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226735 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL389466 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL389237 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL226787 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL226786 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL428685 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267920 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL226788 | — | IC50 | > | 100000.0 | nM | - |