Assay Detail
Binding
CHEMBL890184
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aromatase in JEG3 cell membrane
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | JEG-3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Dual aromatase-steroid sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.61 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226946 | — | — | 1 | 9.74 |
| CHEMBL226790 | — | — | 1 | 9.48 |
| CHEMBL226999 | — | — | 1 | 9.40 |
| CHEMBL226947 | — | — | 1 | 9.30 |
| CHEMBL108425 | — | — | 1 | 9.30 |
| CHEMBL388507 | — | — | 1 | 9.29 |
| CHEMBL390079 | — | — | 1 | 9.22 |
| CHEMBL226892 | — | — | 1 | 9.11 |
| CHEMBL226842 | — | — | 1 | 9.06 |
| CHEMBL390077 | — | — | 1 | 9.04 |
| CHEMBL388506 | — | — | 1 | 8.96 |
| CHEMBL388093 | — | — | 1 | 8.92 |
| CHEMBL390496 | — | — | 1 | 8.82 |
| CHEMBL226789 | — | — | 1 | 8.60 |
| CHEMBL390078 | — | — | 1 | 8.55 |
| CHEMBL226791 | — | — | 1 | 8.55 |
| CHEMBL390717 | — | — | 1 | 8.54 |
| CHEMBL226738 | — | — | 1 | 8.54 |
| CHEMBL226893 | — | — | 1 | 8.41 |
| CHEMBL226843 | — | — | 1 | 8.12 |
| CHEMBL226945 | — | — | 1 | 7.92 |
| CHEMBL388291 | — | — | 1 | 7.64 |
| CHEMBL226841 | — | — | 1 | 7.62 |
| CHEMBL226737 | — | — | 1 | 7.57 |
| CHEMBL226736 | — | — | 1 | 7.38 |
| CHEMBL226891 | — | — | 1 | 6.80 |
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226946 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL226790 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL226999 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL226947 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL108425 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL388507 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL390079 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL226892 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL226842 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL390077 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL388506 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL388093 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL390496 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL226789 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL390078 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL226791 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL390717 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL226738 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL226893 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL226843 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL226945 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL388291 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL226841 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL226737 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL226736 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL226891 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL286738 | IROSUSTAT | IC50 | - | — | - |