Assay Detail
Binding
CHEMBL890212
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Binding affinity to human PNMT
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.24 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 8.51 |
| CHEMBL281864 | — | — | 1 | 7.25 |
| CHEMBL281289 | — | — | 1 | 6.92 |
| CHEMBL243836 | — | — | 1 | 6.66 |
| CHEMBL26717 | — | — | 1 | 6.55 |
| CHEMBL243834 | — | — | 1 | 6.05 |
| CHEMBL243176 | — | — | 1 | 6.04 |
| CHEMBL27162 | — | — | 1 | 5.82 |
| CHEMBL243835 | — | — | 1 | 5.68 |
| CHEMBL390453 | — | — | 1 | 5.64 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 5.24 |
| CHEMBL413311 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL281864 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL281289 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL243836 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL26717 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL243834 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL243176 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL27162 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL243835 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL390453 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL413311 | — | Ki | = | 33000.0 | nM | 4.48 |