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Assay Detail

CHEMBL890446

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against HUVEC after 24 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HUVEC
Confidence 1 — Organism
Curated By Autocuration

Target

HUVEC (CHEMBL613979)
Type CELL-LINE
Organism Homo sapiens

Publication

In-silico fragment-based identification of novel angiogenesis inhibitors.
Dakshanamurthy S, Kim M, Brown ML, Byers SW.
Bioorg Med Chem Lett (2007) 17 : 4551 -4556
PubMed 17591441 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.18 4.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL425653 1 4.89
CHEMBL230243 1 4.20
CHEMBL229030 1 4.13
CHEMBL230022 1 4.12
CHEMBL375673 1 4.09
CHEMBL44 GENISTEIN 2.0 1 4.06
CHEMBL229082 1 4.06
CHEMBL375672 1 4.05
CHEMBL397252 1 4.00
CHEMBL30707 COUMESTROL 1 -
CHEMBL231190 1 -
CHEMBL230023 1 -
CHEMBL230129 1 -
CHEMBL230244 1 -
CHEMBL95599 1 -
CHEMBL231416 1 -
CHEMBL229031 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL425653 IC50 = 13000.0 nM 4.89
CHEMBL230243 IC50 = 63000.0 nM 4.20
CHEMBL229030 IC50 = 74000.0 nM 4.13
CHEMBL230022 IC50 = 75000.0 nM 4.12
CHEMBL375673 IC50 = 82000.0 nM 4.09
CHEMBL44 GENISTEIN IC50 = 88000.0 nM 4.06
CHEMBL229082 IC50 = 88000.0 nM 4.06
CHEMBL375672 IC50 = 90000.0 nM 4.05
CHEMBL397252 IC50 = 100000.0 nM 4.00
CHEMBL30707 COUMESTROL IC50 - -
CHEMBL231190 IC50 - -
CHEMBL230023 IC50 - -
CHEMBL230129 IC50 - -
CHEMBL230244 IC50 - -
CHEMBL95599 IC50 - -
CHEMBL231416 IC50 - -
CHEMBL229031 IC50 - -