Assay Detail
Binding
CHEMBL890447
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Inhibition of human procollagen C-proteinase expressed in CHO cells
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 7.59 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389491 | — | — | 1 | 8.74 |
| CHEMBL226748 | — | — | 1 | 8.70 |
| CHEMBL226697 | — | — | 1 | 8.52 |
| CHEMBL226777 | — | — | 1 | 8.52 |
| CHEMBL226840 | — | — | 1 | 8.52 |
| CHEMBL226725 | — | — | 1 | 8.30 |
| CHEMBL226853 | — | — | 1 | 8.22 |
| CHEMBL373953 | — | — | 1 | 8.22 |
| CHEMBL226746 | — | — | 1 | 8.22 |
| CHEMBL437488 | — | — | 1 | 8.22 |
| CHEMBL229813 | — | — | 1 | 8.22 |
| CHEMBL229814 | — | — | 1 | 8.22 |
| CHEMBL439012 | — | — | 1 | 8.15 |
| CHEMBL226957 | — | — | 1 | 8.10 |
| CHEMBL229866 | — | — | 1 | 8.10 |
| CHEMBL226852 | — | — | 1 | 8.00 |
| CHEMBL229812 | — | — | 1 | 8.00 |
| CHEMBL389020 | — | — | 1 | 7.96 |
| CHEMBL390931 | — | — | 1 | 7.89 |
| CHEMBL373951 | — | — | 1 | 7.89 |
| CHEMBL226800 | — | — | 1 | 7.85 |
| CHEMBL376115 | — | — | 1 | 7.85 |
| CHEMBL226889 | — | — | 1 | 7.85 |
| CHEMBL227153 | — | — | 1 | 7.82 |
| CHEMBL226890 | — | — | 1 | 7.77 |
| CHEMBL226903 | — | — | 1 | 7.77 |
| CHEMBL375964 | — | — | 1 | 7.77 |
| CHEMBL447539 | — | — | 1 | 7.77 |
| CHEMBL226956 | — | — | 1 | 7.75 |
| CHEMBL390930 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389491 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL226748 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL226777 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL226840 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL226697 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL226725 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL226853 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL373953 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL226746 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL437488 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL229813 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL229814 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL439012 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL229866 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL226957 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL226852 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL229812 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL389020 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL390931 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL373951 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL226800 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL376115 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL226889 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL227153 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL447539 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL226903 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL226890 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL375964 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL226956 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL390930 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL427430 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL427289 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL229380 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL434925 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL374399 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL388198 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL276128 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL226747 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL389021 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL227101 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL427427 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL226958 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL373952 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL229324 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL229759 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL226902 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL226799 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL229867 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL226695 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL226942 | — | IC50 | = | 33.0 | nM | 7.48 |