Assay Detail
Binding
CHEMBL890449
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Inhibition of MMP2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.06 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154551 | — | — | 1 | 6.87 |
| CHEMBL154040 | — | — | 1 | 6.00 |
| CHEMBL229375 | — | — | 1 | 5.23 |
| CHEMBL226852 | — | — | 1 | 4.10 |
| CHEMBL374840 | — | — | 1 | 4.10 |
| CHEMBL439012 | — | — | 1 | 4.04 |
| CHEMBL226840 | — | — | 1 | - |
| CHEMBL389020 | — | — | 1 | - |
| CHEMBL229866 | — | — | 1 | - |
| CHEMBL437488 | — | — | 1 | - |
| CHEMBL226853 | — | — | 1 | - |
| CHEMBL226630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154551 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL154040 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL229375 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL226852 | — | IC50 | = | 79600.0 | nM | 4.10 |
| CHEMBL374840 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL439012 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL226840 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL229866 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL437488 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL226853 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL226630 | — | IC50 | > | 10000.0 | nM | - |