Assay Detail
Functional
CHEMBL890505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive cardenolides from the stems and twigs of Nerium oleander.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.60 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229533 | — | — | 1 | 6.80 |
| CHEMBL229258 | — | — | 1 | 6.51 |
| CHEMBL374839 | — | — | 1 | 6.44 |
| CHEMBL229259 | — | — | 1 | 6.32 |
| CHEMBL375518 | — | — | 1 | 5.75 |
| CHEMBL229260 | — | — | 1 | 5.23 |
| CHEMBL1162954 | — | — | 1 | 4.77 |
| CHEMBL229203 | — | — | 1 | 4.34 |
| CHEMBL388861 | — | — | 1 | 4.26 |
| CHEMBL413068 | — | — | 1 | - |
| CHEMBL375720 | — | — | 1 | - |
| CHEMBL229373 | — | — | 1 | - |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229533 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL229258 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL374839 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL229259 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL375518 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL229260 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1162954 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL229203 | — | IC50 | = | 45600.0 | nM | 4.34 |
| CHEMBL388861 | — | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL413068 | — | IC50 | - | — | - | |
| CHEMBL375720 | — | IC50 | - | — | - | |
| CHEMBL229373 | — | IC50 | - | — | - | |
| CHEMBL1453 | DIGITOXIGENIN | IC50 | - | — | - |