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Assay Detail

CHEMBL890747

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-MC
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-MC (CHEMBL614163)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
Kalinowski DS, Yu Y, Sharpe PC, Islam M, Liao YT, Lovejoy DB, Kumar N, Bernhardt PV, Richardson DR.
J Med Chem (2007) 50 : 3716 -3729
PubMed 17602603 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.22 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL385064 1 9.00
CHEMBL442071 1 8.70
CHEMBL395259 1 8.40
CHEMBL230593 1 8.40
CHEMBL231621 1 8.40
CHEMBL396985 1 8.30
CHEMBL275925 1 8.00
CHEMBL396764 1 7.89
CHEMBL394814 1 7.85
CHEMBL230700 1 7.40
CHEMBL216895 1 7.30
CHEMBL413443 1 7.10
CHEMBL394813 1 6.89
CHEMBL231616 TRIAPINE 3.0 1 6.58
CHEMBL438288 1 6.57
CHEMBL390195 1 6.15
CHEMBL385873 1 5.45
CHEMBL394568 1 5.42
CHEMBL556 DEFEROXAMINE 4.0 1 5.35
CHEMBL231041 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL385064 IC50 = 1.0 nM 9.00
CHEMBL442071 IC50 = 2.0 nM 8.70
CHEMBL395259 IC50 = 4.0 nM 8.40
CHEMBL230593 IC50 = 4.0 nM 8.40
CHEMBL231621 IC50 = 4.0 nM 8.40
CHEMBL396985 IC50 = 5.0 nM 8.30
CHEMBL275925 IC50 = 10.0 nM 8.00
CHEMBL396764 IC50 = 13.0 nM 7.89
CHEMBL394814 IC50 = 14.0 nM 7.85
CHEMBL230700 IC50 = 40.0 nM 7.40
CHEMBL216895 IC50 = 50.0 nM 7.30
CHEMBL413443 IC50 = 80.0 nM 7.10
CHEMBL394813 IC50 = 130.0 nM 6.89
CHEMBL231616 TRIAPINE IC50 = 260.0 nM 6.58
CHEMBL438288 IC50 = 270.0 nM 6.57
CHEMBL390195 IC50 = 710.0 nM 6.15
CHEMBL385873 IC50 = 3520.0 nM 5.45
CHEMBL394568 IC50 = 3820.0 nM 5.42
CHEMBL556 DEFEROXAMINE IC50 = 4510.0 nM 5.35
CHEMBL231041 IC50 = 4660.0 nM 5.33