Assay Detail
ADMET
CHEMBL890748
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Antiproliferative activity against human MRC5 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.66 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396985 | — | — | 1 | 5.73 |
| CHEMBL394814 | — | — | 1 | 5.64 |
| CHEMBL396764 | — | — | 1 | 5.62 |
| CHEMBL231621 | — | — | 1 | - |
| CHEMBL395259 | — | — | 1 | - |
| CHEMBL442071 | — | — | 1 | - |
| CHEMBL230593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396985 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL394814 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL396764 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL231621 | — | IC50 | > | 6250.0 | nM | - |
| CHEMBL395259 | — | IC50 | > | 6250.0 | nM | - |
| CHEMBL442071 | — | IC50 | > | 6250.0 | nM | - |
| CHEMBL230593 | — | IC50 | > | 6250.0 | nM | - |