Assay Detail
Functional
CHEMBL890913
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Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antiviral activity of berberine and related compounds against human cytomegalovirus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.17 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396263 | — | — | 1 | 6.28 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | 6.17 |
| CHEMBL11733 | — | — | 1 | 6.06 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.04 |
| CHEMBL435734 | ARCTIGENIN | — | 1 | 5.68 |
| CHEMBL490533 | CANADINE | — | 1 | 4.92 |
| CHEMBL388452 | ARCTIIN | — | 1 | 4.80 |
| CHEMBL233061 | — | — | 1 | 4.77 |
| CHEMBL98123 | PAPAVERINE HYDROCHLORIDE | 2.0 | 1 | 4.68 |
| CHEMBL74675 | — | — | 1 | 4.58 |
| CHEMBL233063 | — | — | 1 | 4.04 |
| CHEMBL11848 | DIHYDROBERBERINE | — | 1 | 4.03 |
| CHEMBL233062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396263 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL11733 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL435734 | ARCTIGENIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL490533 | CANADINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL388452 | ARCTIIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL233061 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL98123 | PAPAVERINE HYDROCHLORIDE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL74675 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL233063 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL11848 | DIHYDROBERBERINE | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL233062 | — | IC50 | > | 200000.0 | nM | - |