Assay Detail
Binding
CHEMBL891120
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Inhibition of mushroom tyrosinase
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.43 | 6.00 |
| Ki | 1 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244249 | — | — | 2 | 6.00 |
| CHEMBL244248 | — | — | 1 | 5.51 |
| CHEMBL394855 | — | — | 1 | 5.30 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.92 |
| CHEMBL129371 | 2',4',6-TRIHYDROXYCHALCONE | — | 1 | - |
| CHEMBL243831 | — | — | 1 | - |
| CHEMBL429284 | — | — | 1 | - |
| CHEMBL243619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244249 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL244248 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL244249 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL394855 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL129371 | 2',4',6-TRIHYDROXYCHALCONE | IC50 | = | 120000.0 | nM | - |
| CHEMBL243831 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL429284 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL243619 | — | IC50 | = | 193000.0 | nM | - |