Assay Detail
Functional
CHEMBL891240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SW620 cells by soft agar assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.94 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.68 |
| CHEMBL438485 | — | — | 1 | 4.60 |
| CHEMBL242753 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL438485 | — | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL242753 | — | EC50 | = | 28200.0 | nM | 4.55 |