Assay Detail
Binding
CHEMBL891342
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Inhibition of calcium channel L type in IMR32 cells
41
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.15 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 6.11 |
| CHEMBL29188 | LOMERIZINE | 2.0 | 1 | 5.83 |
| CHEMBL412849 | — | — | 1 | 5.70 |
| CHEMBL234510 | — | — | 1 | 5.68 |
| CHEMBL245171 | — | — | 1 | 5.66 |
| CHEMBL231820 | — | — | 1 | 5.63 |
| CHEMBL390705 | — | — | 1 | 5.54 |
| CHEMBL389993 | — | — | 1 | 5.51 |
| CHEMBL234915 | — | — | 1 | 5.38 |
| CHEMBL232848 | — | — | 1 | 5.37 |
| CHEMBL234916 | — | — | 1 | 5.37 |
| CHEMBL234490 | — | — | 1 | 5.34 |
| CHEMBL395982 | — | — | 1 | 5.33 |
| CHEMBL243019 | — | — | 1 | 5.26 |
| CHEMBL268157 | — | — | 1 | 5.26 |
| CHEMBL231799 | — | — | 1 | 5.21 |
| CHEMBL395109 | — | — | 1 | 5.18 |
| CHEMBL234943 | — | — | 1 | 5.13 |
| CHEMBL234914 | — | — | 1 | 5.09 |
| CHEMBL245173 | — | — | 1 | 5.09 |
| CHEMBL234938 | — | — | 1 | 5.08 |
| CHEMBL390703 | — | — | 1 | 5.02 |
| CHEMBL233855 | — | — | 1 | 5.00 |
| CHEMBL389103 | — | — | 1 | 4.99 |
| CHEMBL232032 | — | — | 1 | 4.99 |
| CHEMBL390704 | — | — | 1 | 4.94 |
| CHEMBL234491 | — | — | 1 | 4.93 |
| CHEMBL398157 | — | — | 1 | 4.90 |
| CHEMBL232849 | — | — | 2 | 4.89 |
| CHEMBL394578 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL29188 | LOMERIZINE | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL412849 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL234510 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL245171 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL231820 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL390705 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL389993 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL234915 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL234916 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL232848 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL234490 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL395982 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL268157 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL243019 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL231799 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL395109 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL234943 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL234914 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL245173 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL234938 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL390703 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL233855 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL389103 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL232032 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL390704 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL234491 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL398157 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL398158 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL232849 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL394578 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL234698 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL234273 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL232034 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL390187 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL231826 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL398158 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL232849 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL234274 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL234511 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL234719 | — | IC50 | > | 30000.0 | nM | - |