Assay Detail
Binding
CHEMBL891412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha converting enzyme
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.37 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234270 | — | — | 1 | 8.30 |
| CHEMBL321556 | — | — | 1 | 8.00 |
| CHEMBL233852 | — | — | 1 | 7.96 |
| CHEMBL243022 | — | — | 1 | 7.89 |
| CHEMBL233473 | — | — | 1 | 7.57 |
| CHEMBL389594 | — | — | 1 | 7.55 |
| CHEMBL243024 | — | — | 1 | 7.48 |
| CHEMBL243874 | — | — | 1 | 7.28 |
| CHEMBL243236 | — | — | 1 | 7.26 |
| CHEMBL412796 | — | — | 1 | 6.28 |
| CHEMBL427871 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234270 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL321556 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL233852 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL243022 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL233473 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL389594 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL243024 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL243874 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL243236 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL412796 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL427871 | — | Ki | = | 3400.0 | nM | 5.47 |