Assay Detail
Binding
CHEMBL891413
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Inhibition of MMP2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.04 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321556 | — | — | 1 | 7.57 |
| CHEMBL389594 | — | — | 1 | 5.30 |
| CHEMBL243874 | — | — | 1 | 5.24 |
| CHEMBL243236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321556 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL389594 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL243874 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL243236 | — | Ki | > | 3000.0 | nM | - |