Assay Detail
Binding
CHEMBL891416
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Inhibition of MMP9
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.64 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243236 | — | — | 1 | 7.05 |
| CHEMBL389594 | — | — | 1 | 6.70 |
| CHEMBL243874 | — | — | 1 | 6.70 |
| CHEMBL321556 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243236 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL389594 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL243874 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL321556 | — | Ki | = | 800.0 | nM | 6.10 |