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Assay Detail

CHEMBL891432

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant cathepsin L
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Acyclic, orally bioavailable ketone-based cathepsin K inhibitors.
Barrett DG, Catalano JG, Deaton DN, Long ST, McFadyen RB, Miller AB, Miller LR, Samano V, Tavares FX, Wells-Knecht KJ, Wright LL, Zhou HQ.
Bioorg Med Chem Lett (2007) 17 : 22 -27
PubMed 17157021 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.97 8.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL234367 1 8.06
CHEMBL232713 1 7.80
CHEMBL232712 1 7.42
CHEMBL393354 1 7.42
CHEMBL232520 1 7.00
CHEMBL233706 1 5.96
CHEMBL393673 1 5.15
CHEMBL232911 1 -
CHEMBL203463 1 -
CHEMBL540964 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL234367 IC50 = 8.7 nM 8.06
CHEMBL232713 IC50 = 16.0 nM 7.80
CHEMBL232712 IC50 = 38.0 nM 7.42
CHEMBL393354 IC50 = 38.0 nM 7.42
CHEMBL232520 IC50 = 100.0 nM 7.00
CHEMBL233706 IC50 = 1100.0 nM 5.96
CHEMBL393673 IC50 = 7100.0 nM 5.15
CHEMBL232911 IC50 > 250.0 nM -
CHEMBL203463 IC50 > 250.0 nM -
CHEMBL540964 IC50 > 250.0 nM -