Assay Detail
Binding
CHEMBL891443
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Inhibition of human recombinant CA12 by CO2 hydration assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.13 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217288 | — | — | 1 | 9.00 |
| CHEMBL386542 | — | — | 1 | 9.00 |
| CHEMBL392485 | — | — | 1 | 8.96 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL384644 | — | — | 1 | 8.49 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.47 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.46 |
| CHEMBL410510 | — | — | 1 | 8.41 |
| CHEMBL215182 | — | — | 1 | 8.41 |
| CHEMBL387076 | — | — | 1 | 8.37 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL216214 | — | — | 1 | 8.21 |
| CHEMBL425274 | — | — | 1 | 8.15 |
| CHEMBL216245 | — | — | 1 | 8.14 |
| CHEMBL216312 | — | — | 1 | 8.13 |
| CHEMBL217303 | — | — | 1 | 8.13 |
| CHEMBL231897 | — | — | 1 | 8.12 |
| CHEMBL216208 | — | — | 1 | 8.12 |
| CHEMBL214926 | — | — | 1 | 8.12 |
| CHEMBL383897 | — | — | 1 | 8.11 |
| CHEMBL215156 | — | — | 1 | 8.11 |
| CHEMBL217304 | — | — | 1 | 8.10 |
| CHEMBL215105 | — | — | 1 | 8.10 |
| CHEMBL217454 | — | — | 1 | 8.09 |
| CHEMBL217569 | — | — | 1 | 8.08 |
| CHEMBL216563 | — | — | 1 | 8.06 |
| CHEMBL231896 | — | — | 1 | 7.94 |
| CHEMBL385152 | — | — | 1 | 7.94 |
| CHEMBL394021 | — | — | 1 | 7.93 |
| CHEMBL216210 | — | — | 1 | 7.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217288 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL386542 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL392485 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL384644 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL410510 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL215182 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL387076 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL216214 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL425274 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL216245 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL217303 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL216312 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL214926 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL231897 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL216208 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL383897 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL215156 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL217304 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL215105 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL217454 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL217569 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL216563 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL231896 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL385152 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL394021 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL216210 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL386416 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL386266 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL217232 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL217683 | — | Ki | = | 388.0 | nM | 6.41 |