Assay Detail
Binding
CHEMBL891832
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Inhibition of Hsp90-dependent luciferase renaturation in rabbit reticulocyte after 30 mins by luciferase refolding assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.09 | 6.92 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243379 | — | — | 1 | 6.92 |
| CHEMBL391976 | — | — | 1 | 5.72 |
| CHEMBL373839 | — | — | 1 | 5.68 |
| CHEMBL244856 | — | — | 1 | 5.36 |
| CHEMBL243378 | — | — | 1 | 5.35 |
| CHEMBL244649 | — | — | 1 | 5.17 |
| CHEMBL244645 | — | — | 1 | 5.16 |
| CHEMBL242070 | — | — | 1 | 4.89 |
| CHEMBL244644 | — | — | 1 | 4.82 |
| CHEMBL244857 | — | — | 1 | 4.82 |
| CHEMBL267604 | — | — | 1 | 4.82 |
| CHEMBL244858 | — | — | 1 | 4.80 |
| CHEMBL244648 | — | — | 1 | 4.66 |
| CHEMBL397442 | — | — | 1 | 4.64 |
| CHEMBL395576 | — | — | 1 | 4.44 |
| CHEMBL244440 | — | — | 1 | 4.26 |
| CHEMBL395021 | — | — | 1 | - |
| CHEMBL244859 | — | — | 1 | - |
| CHEMBL388919 | — | — | 1 | - |
| CHEMBL242071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243379 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL391976 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL373839 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL244856 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL243378 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL244649 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL244645 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL242070 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL244644 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL244857 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL267604 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL244858 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL244648 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL397442 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL395576 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL244440 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL395021 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL244859 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL388919 | — | Activity | - | — | - | |
| CHEMBL242071 | — | Activity | - | — | - |