Assay Detail
Functional
CHEMBL891833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against MCF7 cells after 72 hrs
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.82 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391976 | — | — | 1 | 5.68 |
| CHEMBL244858 | — | — | 1 | 5.52 |
| CHEMBL395576 | — | — | 1 | 5.40 |
| CHEMBL244649 | — | — | 1 | 5.04 |
| CHEMBL395021 | — | — | 1 | 4.72 |
| CHEMBL244645 | — | — | 1 | 4.60 |
| CHEMBL243378 | — | — | 1 | 4.47 |
| CHEMBL242071 | — | — | 1 | 4.39 |
| CHEMBL244857 | — | — | 1 | 4.36 |
| CHEMBL397442 | — | — | 1 | 4.03 |
| CHEMBL242070 | — | — | 1 | - |
| CHEMBL388919 | — | — | 1 | - |
| CHEMBL244644 | — | — | 1 | - |
| CHEMBL244856 | — | — | 1 | - |
| CHEMBL243379 | — | — | 1 | - |
| CHEMBL244440 | — | — | 1 | - |
| CHEMBL244859 | — | — | 1 | - |
| CHEMBL373839 | — | — | 1 | - |
| CHEMBL267604 | — | — | 1 | - |
| CHEMBL244648 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391976 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL244858 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL395576 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL244649 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL395021 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL244645 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL243378 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL242071 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL244857 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL397442 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL242070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL388919 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244644 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244856 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL243379 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244440 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244859 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL373839 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL267604 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244648 | — | IC50 | > | 100000.0 | nM | - |