Assay Detail
Functional
CHEMBL891835
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Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.66 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244858 | — | — | 1 | 5.36 |
| CHEMBL395021 | — | — | 1 | 5.33 |
| CHEMBL244645 | — | — | 1 | 5.05 |
| CHEMBL244649 | — | — | 1 | 4.96 |
| CHEMBL391976 | — | — | 1 | 4.90 |
| CHEMBL267604 | — | — | 1 | 4.67 |
| CHEMBL395576 | — | — | 1 | 4.48 |
| CHEMBL397442 | — | — | 1 | 4.36 |
| CHEMBL243378 | — | — | 1 | 4.29 |
| CHEMBL244857 | — | — | 1 | 4.21 |
| CHEMBL242071 | — | — | 1 | 4.19 |
| CHEMBL242070 | — | — | 1 | 4.17 |
| CHEMBL373839 | — | — | 1 | - |
| CHEMBL244648 | — | — | 1 | - |
| CHEMBL244440 | — | — | 1 | - |
| CHEMBL244859 | — | — | 1 | - |
| CHEMBL243379 | — | — | 1 | - |
| CHEMBL244856 | — | — | 1 | - |
| CHEMBL244644 | — | — | 1 | - |
| CHEMBL388919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244858 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL395021 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL244645 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL244649 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL391976 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL267604 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL395576 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL397442 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL243378 | — | IC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL244857 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL242071 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL242070 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL373839 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244440 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244859 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL243379 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244856 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244644 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL388919 | — | IC50 | > | 100000.0 | nM | - |