Assay Detail
Functional
CHEMBL891889
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Inhibition of DNA synthesis in human RPMI cells by [3H]-thymidine incorporation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428715 | 3-DEOXYSCHWEINFURTHIN B | — | 1 | 6.68 |
| CHEMBL376007 | SCHWEINFURTHIN F | — | 1 | 6.24 |
| CHEMBL232643 | — | — | 1 | 5.47 |
| CHEMBL388469 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428715 | 3-DEOXYSCHWEINFURTHIN B | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL376007 | SCHWEINFURTHIN F | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL232643 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL388469 | — | IC50 | = | 4500.0 | nM | 5.35 |