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Assay Detail

CHEMBL892200

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).
Gebhardt P, Dornberger K, Gollmick FA, Gräfe U, Härtl A, Görls H, Schlegel B, Hertweck C.
Bioorg Med Chem Lett (2007) 17 : 2558 -2560
PubMed 17346963 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.71 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL153 TROLOX 1 6.82
CHEMBL232615 1 6.20
CHEMBL6 INDOMETHACIN 4.0 1 4.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL153 TROLOX IC50 = 150.0 nM 6.82
CHEMBL232615 IC50 = 630.0 nM 6.20
CHEMBL6 INDOMETHACIN IC50 = 77100.0 nM 4.11