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Assay Detail

CHEMBL892211

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli primase by scintillation proximity assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Small molecule inhibitors of E. coli primase, a novel bacterial target.
Agarwal A, Louise-May S, Thanassi JA, Podos SD, Cheng J, Thoma C, Liu C, Wiles JA, Nelson DM, Phadke AS, Bradbury BJ, Deshpande MS, Pucci MJ.
Bioorg Med Chem Lett (2007) 17 : 2807 -2810
PubMed 17350255 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.51 5.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL233896 1 5.47
CHEMBL233894 1 5.14
CHEMBL428371 1 4.77
CHEMBL232859 1 4.74
CHEMBL437769 1 4.66
CHEMBL394561 1 4.58
CHEMBL233895 1 4.56
CHEMBL396958 1 4.49
CHEMBL232624 1 4.44
CHEMBL245136 1 4.37
CHEMBL396970 1 4.35
CHEMBL232625 1 4.35
CHEMBL233890 1 4.30
CHEMBL232623 1 4.21
CHEMBL234075 1 4.10
CHEMBL232421 1 4.07
CHEMBL232822 1 4.00
CHEMBL396045 1 -
CHEMBL434001 1 -
CHEMBL396044 1 -
CHEMBL389991 1 -
CHEMBL232824 1 -
CHEMBL438858 1 -
CHEMBL234076 1 -
CHEMBL395285 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL233896 IC50 = 3400.0 nM 5.47
CHEMBL233894 IC50 = 7200.0 nM 5.14
CHEMBL428371 IC50 = 16900.0 nM 4.77
CHEMBL232859 IC50 = 18400.0 nM 4.74
CHEMBL437769 IC50 = 22000.0 nM 4.66
CHEMBL394561 IC50 = 26600.0 nM 4.58
CHEMBL233895 IC50 = 27300.0 nM 4.56
CHEMBL396958 IC50 = 32300.0 nM 4.49
CHEMBL232624 IC50 = 36000.0 nM 4.44
CHEMBL245136 IC50 = 42500.0 nM 4.37
CHEMBL396970 IC50 = 44700.0 nM 4.35
CHEMBL232625 IC50 = 45000.0 nM 4.35
CHEMBL233890 IC50 = 50500.0 nM 4.30
CHEMBL232623 IC50 = 61000.0 nM 4.21
CHEMBL234075 IC50 = 79200.0 nM 4.10
CHEMBL232421 IC50 = 85100.0 nM 4.07
CHEMBL232822 IC50 = 99500.0 nM 4.00
CHEMBL396045 IC50 = 122400.0 nM -
CHEMBL434001 IC50 = 138000.0 nM -
CHEMBL396044 IC50 = 170500.0 nM -
CHEMBL389991 IC50 > 200000.0 nM -
CHEMBL232824 IC50 = 162100.0 nM -
CHEMBL438858 IC50 > 200000.0 nM -
CHEMBL234076 IC50 = 103200.0 nM -
CHEMBL395285 IC50 > 200000.0 nM -