Assay Detail
Binding
CHEMBL892233
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Displacement of [3H]GR-125743 from human 5HT1B expressed in LM(tk-) cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.10 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391273 | — | — | 1 | 7.82 |
| CHEMBL233210 | — | — | 1 | 7.68 |
| CHEMBL3706925 | — | — | 1 | 7.06 |
| CHEMBL234448 | — | — | 1 | 7.04 |
| CHEMBL391271 | — | — | 1 | 6.99 |
| CHEMBL3706923 | — | — | 1 | 6.94 |
| CHEMBL83617 | — | — | 1 | 6.69 |
| CHEMBL234447 | — | — | 1 | 6.55 |
| CHEMBL3706924 | — | — | 1 | - |
| CHEMBL234449 | — | — | 1 | - |
| CHEMBL391272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391273 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL233210 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3706925 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL234448 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL391271 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL3706923 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL83617 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL234447 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL3706924 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL234449 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL391272 | — | Ki | > | 1000.0 | nM | - |