Assay Detail
Binding
CHEMBL892292
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Binding affinity at mouse CCR1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.07 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232441 | — | — | 1 | 6.58 |
| CHEMBL232656 | BX 471 FREE BASE | 2.0 | 1 | 6.21 |
| CHEMBL231829 | — | — | 1 | 6.21 |
| CHEMBL232638 | — | — | 1 | 6.02 |
| CHEMBL232837 | — | — | 1 | 6.01 |
| CHEMBL397910 | — | — | 1 | 6.00 |
| CHEMBL387608 | — | — | 1 | 5.78 |
| CHEMBL234295 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232441 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL232656 | BX 471 FREE BASE | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL231829 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL232638 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL232837 | — | IC50 | = | 968.0 | nM | 6.01 |
| CHEMBL397910 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL387608 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL234295 | — | IC50 | = | 1770.0 | nM | 5.75 |