Assay Detail
Binding
CHEMBL892382
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Inhibition of trypsin-like activity of 20S proteasome in lymphoblastoid cells after 30 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Glutamine vinyl ester proteasome inhibitors selective for trypsin-like (beta2) subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.41 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188918 | — | — | 1 | 7.48 |
| CHEMBL394542 | — | — | 1 | 7.25 |
| CHEMBL245213 | — | — | 1 | 7.01 |
| CHEMBL245211 | — | — | 1 | 6.84 |
| CHEMBL396037 | — | — | 1 | 6.80 |
| CHEMBL396035 | — | — | 1 | 6.46 |
| CHEMBL398215 | — | — | 1 | 6.36 |
| CHEMBL231166 | — | — | 1 | 5.63 |
| CHEMBL396036 | — | — | 1 | 5.23 |
| CHEMBL267478 | — | — | 1 | 5.07 |
| CHEMBL231167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188918 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL394542 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL245213 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL245211 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL396037 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL396035 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL398215 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL231166 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL396036 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL267478 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL231167 | — | IC50 | > | 10000.0 | nM | - |