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Assay Detail

CHEMBL892383

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of chymotrypsin-like activity of 20S proteasome in lymphoblastoid cells after 30 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Glutamine vinyl ester proteasome inhibitors selective for trypsin-like (beta2) subunit.
Baldisserotto A, Marastoni M, Trapella C, Gavioli R, Ferretti V, Pretto L, Tomatis R.
Eur J Med Chem (2007) 42 : 586 -592
PubMed 17291631 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.12 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL396037 1 5.16
CHEMBL245213 1 5.13
CHEMBL245211 1 5.08
CHEMBL188918 1 -
CHEMBL267478 1 -
CHEMBL231167 1 -
CHEMBL396036 1 -
CHEMBL231166 1 -
CHEMBL396035 1 -
CHEMBL398215 1 -
CHEMBL394542 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL396037 IC50 = 6890.0 nM 5.16
CHEMBL245213 IC50 = 7360.0 nM 5.13
CHEMBL245211 IC50 = 8410.0 nM 5.08
CHEMBL188918 IC50 > 10000.0 nM -
CHEMBL267478 IC50 > 10000.0 nM -
CHEMBL231167 IC50 > 10000.0 nM -
CHEMBL396036 IC50 > 10000.0 nM -
CHEMBL231166 IC50 > 10000.0 nM -
CHEMBL396035 IC50 > 10000.0 nM -
CHEMBL398215 IC50 > 10000.0 nM -
CHEMBL394542 IC50 > 10000.0 nM -