Assay Detail
Binding
CHEMBL892513
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Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.05 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245067 | PHLORIZIN | — | 1 | 7.00 |
| CHEMBL243796 | KURARINONE | — | 1 | 5.77 |
| CHEMBL243148 | SOPHORAFLAVANONE G | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245067 | PHLORIZIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL243796 | KURARINONE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL243148 | SOPHORAFLAVANONE G | IC50 | = | 4100.0 | nM | 5.39 |