Assay Detail
Binding
CHEMBL892528
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Inhibition of CDK1/cyclinB
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.81 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235345 | — | — | 1 | 7.64 |
| CHEMBL393929 | — | — | 1 | 7.46 |
| CHEMBL391888 | — | — | 1 | 7.42 |
| CHEMBL234437 | — | — | 1 | 7.35 |
| CHEMBL236198 | — | — | 1 | 7.34 |
| CHEMBL439380 | — | — | 1 | 7.28 |
| CHEMBL429624 | — | — | 1 | 7.22 |
| CHEMBL234259 | — | — | 1 | 7.22 |
| CHEMBL234441 | — | — | 1 | 7.21 |
| CHEMBL232988 | — | — | 1 | 7.20 |
| CHEMBL396377 | — | — | 1 | 7.10 |
| CHEMBL235123 | — | — | 1 | 7.07 |
| CHEMBL233411 | — | — | 1 | 7.06 |
| CHEMBL391506 | — | — | 1 | 7.05 |
| CHEMBL429625 | — | — | 1 | 6.92 |
| CHEMBL233587 | — | — | 1 | 6.89 |
| CHEMBL233197 | — | — | 1 | 6.82 |
| CHEMBL393157 | — | — | 1 | 6.64 |
| CHEMBL393103 | — | — | 1 | 6.62 |
| CHEMBL233195 | — | — | 1 | 6.57 |
| CHEMBL394253 | — | — | 1 | 6.57 |
| CHEMBL429621 | — | — | 1 | 6.55 |
| CHEMBL233203 | — | — | 1 | 6.51 |
| CHEMBL233196 | — | — | 1 | 6.51 |
| CHEMBL393357 | — | — | 1 | 6.46 |
| CHEMBL393358 | — | — | 1 | 6.41 |
| CHEMBL269296 | — | — | 1 | 6.41 |
| CHEMBL394138 | — | — | 1 | 6.39 |
| CHEMBL235343 | — | — | 1 | 6.24 |
| CHEMBL232605 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235345 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL393929 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL391888 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL234437 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL236198 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL439380 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL429624 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL234259 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL234441 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL232988 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL396377 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL235123 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL233411 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL391506 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL429625 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL233587 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL233197 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL393157 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL393103 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL394253 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL233195 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL429621 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL233203 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL233196 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL393357 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL393358 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL269296 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL394138 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL235343 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL232605 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL235124 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL235125 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL234052 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL392896 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL235344 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL235566 | — | Ki | > | 2000.0 | nM | - |