Assay Detail
Functional
CHEMBL892540
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Antiproliferative activity against human HCT116 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393929 | — | — | 1 | 5.94 |
| CHEMBL393157 | — | — | 1 | 5.80 |
| CHEMBL235345 | — | — | 1 | 5.62 |
| CHEMBL396377 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393929 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL393157 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL235345 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL396377 | — | IC50 | = | 2530.0 | nM | 5.60 |