Assay Detail
Functional
CHEMBL892541
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Antiproliferative activity against human H460a cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H460a |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.77 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393929 | — | — | 1 | 5.98 |
| CHEMBL396377 | — | — | 1 | 5.74 |
| CHEMBL235345 | — | — | 1 | 5.60 |
| CHEMBL393157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393929 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL396377 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL235345 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL393157 | — | IC50 | - | — | - |