Assay Detail
Binding
CHEMBL892636
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Inhibition of xanthine oxidase
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.09 | 5.09 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244743 | ESCULETIN | — | 1 | 5.09 |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | — | 1 | - |
| CHEMBL313244 | 4-METHYLESCULETIN | — | 1 | - |
| CHEMBL71851 | SCOPOLETIN | — | 1 | - |
| CHEMBL390320 | ISOSCOPOLETIN | — | 1 | - |
| CHEMBL244948 | DAPHNETIN | -1.0 | 1 | - |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
| CHEMBL301141 | 4-HYDROXYCOUMARINS | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244743 | ESCULETIN | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | IC50 | = | 131000.0 | nM | - |
| CHEMBL313244 | 4-METHYLESCULETIN | IC50 | = | 246000.0 | nM | - |
| CHEMBL71851 | SCOPOLETIN | Activity | - | — | - | |
| CHEMBL390320 | ISOSCOPOLETIN | IC50 | = | 138000.0 | nM | - |
| CHEMBL244948 | DAPHNETIN | IC50 | = | 390000.0 | nM | - |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 236000.0 | nM | - |
| CHEMBL301141 | 4-HYDROXYCOUMARINS | IC50 | = | 195000.0 | nM | - |