Assay Detail
Binding
CHEMBL892675
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Inhibition of FTase by SPA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.49 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243659 | (S)-TIPIFARNIB | — | 1 | 9.05 |
| CHEMBL388241 | — | — | 1 | 9.00 |
| CHEMBL395718 | — | — | 1 | 9.00 |
| CHEMBL341586 | — | — | 1 | 8.46 |
| CHEMBL337751 | — | — | 1 | 8.46 |
| CHEMBL395964 | — | — | 1 | 8.40 |
| CHEMBL244907 | — | — | 1 | 8.30 |
| CHEMBL394371 | — | — | 1 | 7.96 |
| CHEMBL242594 | — | — | 1 | 7.80 |
| CHEMBL244724 | — | — | 1 | - |
| CHEMBL243660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243659 | (S)-TIPIFARNIB | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL388241 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL395718 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL341586 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL337751 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL395964 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL244907 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL394371 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL242594 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL244724 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL243660 | — | IC50 | > | 100.0 | nM | - |