Assay Detail
Binding
CHEMBL892685
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Inhibition of rat endothelial NOS activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.32 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233655 | — | — | 1 | 5.89 |
| CHEMBL233652 | — | — | 1 | 5.47 |
| CHEMBL233653 | — | — | 1 | 5.34 |
| CHEMBL233654 | — | — | 1 | 5.28 |
| CHEMBL412797 | — | — | 1 | 5.04 |
| CHEMBL233857 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233655 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL233652 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL233653 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL233654 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL412797 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL233857 | — | IC50 | = | 12500.0 | nM | 4.90 |