Assay Detail
Functional
CHEMBL892762
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Cytotoxicity against human A549 cells by MTT microassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.75 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.51 |
| CHEMBL242335 | — | — | 1 | 5.42 |
| CHEMBL242977 | — | — | 1 | 5.35 |
| CHEMBL242123 | — | — | 1 | 4.96 |
| CHEMBL396806 | — | — | 1 | 4.83 |
| CHEMBL242749 | — | — | 1 | 4.66 |
| CHEMBL242978 | — | — | 1 | 4.65 |
| CHEMBL242734 | — | — | 1 | 4.55 |
| CHEMBL243198 | — | — | 1 | 4.53 |
| CHEMBL397045 | — | — | 1 | 4.43 |
| CHEMBL243197 | — | — | 1 | 4.40 |
| CHEMBL242976 | — | — | 1 | 4.29 |
| CHEMBL243199 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL242335 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL242977 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL242123 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL396806 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL242749 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL242978 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL242734 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL243198 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL397045 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL243197 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL242976 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL243199 | — | IC50 | = | 60400.0 | nM | 4.22 |