Assay Detail
Functional
CHEMBL892765
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Cytotoxicity against human MCF7 cells by MTT microassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.17 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.82 |
| CHEMBL242977 | — | — | 1 | 5.58 |
| CHEMBL242335 | — | — | 1 | 5.43 |
| CHEMBL242123 | — | — | 1 | 5.42 |
| CHEMBL243199 | — | — | 1 | 5.39 |
| CHEMBL397045 | — | — | 1 | 5.19 |
| CHEMBL242978 | — | — | 1 | 5.12 |
| CHEMBL242976 | — | — | 1 | 4.99 |
| CHEMBL242734 | — | — | 1 | 4.98 |
| CHEMBL396806 | — | — | 1 | 4.96 |
| CHEMBL243198 | — | — | 1 | 4.90 |
| CHEMBL242749 | — | — | 1 | 4.74 |
| CHEMBL243197 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL242977 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL242335 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL242123 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL243199 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL397045 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL242978 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL242976 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL242734 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL396806 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL243198 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL242749 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL243197 | — | IC50 | = | 19000.0 | nM | 4.72 |