Assay Detail
Functional
CHEMBL892775
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Inhibition of beta-glucuronidase release from rat mast cells
12
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.20 | 5.66 |
| Inhibition | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 5.66 |
| CHEMBL242734 | — | — | 1 | 4.74 |
| CHEMBL242123 | — | — | 2 | - |
| CHEMBL243197 | — | — | 2 | - |
| CHEMBL396806 | — | — | 2 | - |
| CHEMBL242977 | — | — | 2 | - |
| CHEMBL242976 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL242734 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL242123 | — | Inhibition | = | -4.6 | % | - |
| CHEMBL243197 | — | Inhibition | = | -11.2 | % | - |
| CHEMBL396806 | — | Inhibition | = | -13.3 | % | - |
| CHEMBL242977 | — | Inhibition | = | -2.7 | % | - |
| CHEMBL242976 | — | Inhibition | = | 12.7 | % | - |
| CHEMBL242123 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL242977 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL242976 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL396806 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL243197 | — | IC50 | > | 30000.0 | nM | - |