Assay Detail
Binding
CHEMBL892851
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Inhibition of NADH-ubiquinone oxidoreductase activity in bovine heart submitochondrial particles
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.55 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159657 | BULLATACIN | — | 1 | 9.08 |
| CHEMBL396297 | CIS-SOLAMIN | — | 1 | 8.59 |
| CHEMBL157184 | DIHYDROXY-COHIBIN A | — | 1 | 7.70 |
| CHEMBL245073 | — | — | 1 | 6.24 |
| CHEMBL395578 | TONKINELIN | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159657 | BULLATACIN | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL396297 | CIS-SOLAMIN | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL157184 | DIHYDROXY-COHIBIN A | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL245073 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL395578 | TONKINELIN | IC50 | = | 690.0 | nM | 6.16 |