Assay Detail
Binding
CHEMBL892966
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Inhibition of human trypsin
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.51 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244219 | — | — | 1 | 5.96 |
| CHEMBL244221 | — | — | 1 | 5.60 |
| CHEMBL244436 | — | — | 1 | 5.57 |
| CHEMBL19902 | DX-9065A | — | 1 | 5.50 |
| CHEMBL244640 | — | — | 1 | 5.43 |
| CHEMBL390266 | — | — | 1 | 5.28 |
| CHEMBL244641 | — | — | 1 | 5.22 |
| CHEMBL244435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244219 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL244221 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL244436 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL19902 | DX-9065A | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL244640 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL390266 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL244641 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL244435 | — | IC50 | - | — | - |